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Best SSRIs for depression (all time)

A ranking of selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) drugs in terms of their efficiency in treating depression; major depressive disorder (MDD).

Year:
Loc:
Citalopram
1

Citalopram

(1989)
Citalopram (brand names: Celexa, Cipramil) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. It has U.S. Food and Drug Administration approval to treat major depression, which it received in 199...
6.5
6.5
[graph]
from 2 votes
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Fluoxetine (Prozac)
2

Fluoxetine (Prozac)

(1987)
Fluoxetine (trade names Prozac, Sarafem, Seronil, Rapiflux, Selfemra, and other) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Fluoxetine was discovered and developed by scientists from Eli Lilly...
3.8
3.8
[graph]
from 4 votes
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Fluvoxamine
3

Fluvoxamine

(1983)
Fluvoxamine (brand names: Faverin, Fevarin, Floxyfral, Luvox, Solvay, and other) is a medication which functions as a selective serotonin reuptake inhibitor (SSRI) and σ1 receptor agonist. Fluvoxamine is used primarily for the tre...
3
3
[graph]
from 1 vote
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Escitalopram
4

Escitalopram

(2002)
Escitalopram, brand names Lexapro and Cipralex among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of adult...
2
2
[graph]
from 2 votes
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Milnacipran
5

Milnacipran

(1996)
Milnacipran (brand names Ixel, Savella, Dalcipran, Toledomin) is a serotonin–norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressiv...
2
2
[graph]
from 1 vote
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Levomilnacipran
5

Levomilnacipran

(2013)
Levomilnacipran (brand name Fetzima) is an antidepressant approved for the treatment of major depressive disorder in the United States. It was developed by Forest Laboratories and Pierre Fabre Group, and was approved by the Food a...
2
2
[graph]
from 1 vote
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Duloxetine
5

Duloxetine

(2004)
Duloxetine (brand names Cymbalta, Yentreve, and other) is a serotonin-norepinephrine reuptake inhibitor (SNRI) created by Eli Lilly. It is mostly prescribed for major depressive disorder, generalized anxiety disorder (GAD), fibrom...
2
2
[graph]
from 1 vote
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Paroxetine
8

Paroxetine

(1992)
Paroxetine (trade name Paxil, Seroxat, Brisdelle, Pexeva, among others) is an antidepressant drug of the SSRI type. Paroxetine is used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, postt...
1.7
1.7
[graph]
from 3 votes
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Desvenlafaxine
9

Desvenlafaxine

(2008)
Desvenlafaxine (brand names: Pristiq, DESFAX), also known as O-desmethylvenlafaxine, is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class developed and marketed by Wyeth (now part of Pfizer). Desven...
1
1
[graph]
from 1 vote
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Sertraline
9

Sertraline

(1991)
Sertraline (brand names Zoloft, Lustral, and other) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily prescribed for major d...
1
1
[graph]
from 1 vote
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Venlafaxine
9

Venlafaxine

(1993)
Venlafaxine (brand names: Effexor, Effexor XR, LanvexinTrevilor, Efectin, Oriven, Velafax, and other) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. This means it increases the concentrations...
1
1
[graph]
from 1 vote
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