List of medications for depression, sorted by date - oldest first (all time)

Piracetam (sold under many brand names) is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid. Piracetam is a cyclic...

Noopept (Russian: Ноопепт; GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) is a peptide promoted and prescribed in Russia and neighbouring countries as a nootropic. The registered brand name Noopept (Ноопепт) is trademarked b...

Fluvoxamine (brand names: Faverin, Fevarin, Floxyfral, Luvox, Solvay, and other) is a medication which functions as a selective serotonin reuptake inhibitor (SSRI) and σ1 receptor agonist. Fluvoxamine is used primarily for the tre...

Fluoxetine (trade names Prozac, Sarafem, Seronil, Rapiflux, Selfemra, and other) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Fluoxetine was discovered and developed by scientists from Eli Lilly...

Tianeptine (brand names Stablon, Coaxil, Tianeurax, Aneptinex, Atinepte, Neluptin, Lyxit, Neluptin, Tialera, Tianesal, Tatinol, Tianeurax, Salymbra) is a drug used primarily in the treatment of major depressive disorder, although...

Citalopram (brand names: Celexa, Cipramil) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class. It has U.S. Food and Drug Administration approval to treat major depression, which it received in 199...

Sertraline (brand names Zoloft, Lustral, and other) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was introduced to the market by Pfizer in 1991. Sertraline is primarily prescribed for major d...

Paroxetine (trade name Paxil, Seroxat, Brisdelle, Pexeva, among others) is an antidepressant drug of the SSRI type. Paroxetine is used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, postt...

Venlafaxine (brand names: Effexor, Effexor XR, LanvexinTrevilor, Efectin, Oriven, Velafax, and other) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class. This means it increases the concentrations...

Modafinil (brand names Modiodal, Provigil, Modavigil, Vigil, Alertec, and other) is a wakefulness-promoting agent (or eugeroic) used for treatment of wakefulness disorders such as narcolepsy, shift work sleep disorder, and excessi...

Semax (Russian: Семакс) is a drug produced and prescribed mostly in Russia and Ukraine for a broad range of conditions but predominantly for its purported nootropic, neuroprotective, and neurogenic/neurorestorative properties. It...

Milnacipran (brand names Ixel, Savella, Dalcipran, Toledomin) is a serotonin–norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressiv...

Escitalopram, brand names Lexapro and Cipralex among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is approved by the U.S. Food and Drug Administration (FDA) for the treatment of adult...

Duloxetine (brand names Cymbalta, Yentreve, and other) is a serotonin-norepinephrine reuptake inhibitor (SNRI) created by Eli Lilly. It is mostly prescribed for major depressive disorder, generalized anxiety disorder (GAD), fibrom...

Armodafinil (brand names Nuvigil, Acronite, R-Modawake, Artvigil, Waklert) is the enantiopure of the wakefulness-promoting agent, or eugeroic, modafinil (Provigil). It consists of just the (−)-(R)-enantiomer of the racemic modafin...

Desvenlafaxine (brand names: Pristiq, DESFAX), also known as O-desmethylvenlafaxine, is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class developed and marketed by Wyeth (now part of Pfizer). Desven...

Vilazodone (trade name Viibryd) is a serotonergic antidepressant developed by Clinical Data for the treatment of major depressive disorder. The chemical compound was originally developed by Merck KGaA (Germany). Vilazodone was app...

Vortioxetine (trade name Brintellix and Trintellix in Canada) is an atypical antidepressant (a serotonin modulator and stimulator) made by Lundbeck and Takeda. On September 30, 2013, it was approved by the U.S. FDA for the treatme...

Levomilnacipran (brand name Fetzima) is an antidepressant approved for the treatment of major depressive disorder in the United States. It was developed by Forest Laboratories and Pierre Fabre Group, and was approved by the Food a...