I think it depends on the individual man or woman, and it also depends a lot on having a good script, director, etc. I like actors and actresses that are picky about their roles and don't do just anything for a buck. I'm willing to take a look at anything with Hilary Swank in it. I'd say she makes good choices about 80% of the time. When she chooses a bad movie, it's REALLY bad however. Denzel Washington has chosen really good roles for most of his career, but now that he's getting older, I think he's been forced to be less choosy.
I probably choose movies with male leads more often than ones with female leads, but I think it's more a function of men being offered better lead roles and more lead roles in general.